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The optional sidequest where everyone thinks Tristan/Honda has turned into a robot monkey.
Another optional moment where Tea gets hit on by a rock star and the penguin-themed member of the Big Five. This is because of a fortune-teller saying she'd have bad luck with men.
That One Attack: That One Trap, Torrential Tribute, which destroys all non-Divine monsters on the attacking side. Late-game duelists have three of them.
There's also That One Spell, Raigeki, which also destroys all monsters on the opposing team. There's an Anti-Raigeki card to counter it, but the odds of you having one out are slim, thanks to...
Harpie's Feather Duster, which removes all traps and spells from the opponent's field. It's not just Mai that has them, either.
That One Boss: Marik. Justified Trope as he's protecting the power of Ra, though. Making this worse is he's a required boss.
Mako Tsunami is up there, too, especially in the rematch. And God help you if Weevil summons the Perfectly Ultimate Great Moth...
Every duelist in the game can qualify as this considering the horrible cards you start the game with, the low amounts of Deck Capacity you will be getting, and the ability for the computer to topdeck their best cards.
Reshef. 40,000 LP, all three God Cards (despite the fact that YOU have all of them), regenerating LP cards, enough traps and spells to inhibit your attacks, and he comes immediately after another battle. You can have a hard time beating him using ACTION REPLAY.
Odion is somewhere on this spectrum as well, although you can skip him and go straight for Marik instead. At the very least, he's a Wake Up Call Boss, and you had better be prepared if you're confident/foolish enough to try to beat him and Marik back-to-back.
Arkana. With non-tribute monsters beefed up to over 1800 Attack with the Yami field and varied types of monsters, your only prayer for survival is to change the field type or get lucky with Final Destiny. Even then, it's an uphill battle.
Mai Valentine, especially in the rematch.
↑It doesn't necessarily guarantee a win, though, if your opponent can lower its Attack/Defense Points with Effect Cards.
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