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The sequel to Crime Fighters was made in 1991 by Konami. In Japan, it's called Crime Fighters 2. The game has even more humor than the original and unlike Crime Fighters, doesn't suffer from the Fake Difficulty of the previous game.

Taking place in Dead End City, the Dead End Gang seeks to expand their territory. Only their rival gang, the Cobras, can stop them. The Cobras consist of ex-prize fighter Blood, former pro-wrestler Hawk, martial arts expert Boomer, ex-military convict Sledge, and Hawk's protegee, Kate. Kate gets kidnapped by the Dead End gang to lure them into a trap.

This game has examples of:

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