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As depicted in the opening sequence of each episode, the Powerpuff Girls were created by Professor Utonium in an attempt to create the "perfect little girl" using a mixture of sugar, spice, and everything nice. However, he accidentally spilled Chemical X into the mixture, granting the girls their superpowers.

Tropes applying to all three in general

Powers:

Blossom

 Voiced by Cathy Cavadini (1995-2015), Amanda Leighton (2016-present)

 Commander and the leader

Blossom is the redhead in the pink outfit and signature red bow. She's the "smart one" and the self-proclaimed leader of the group, although at times she can be bossy or over-analytical. Her unique ability, introduced in the episode "Ice Sore", is ice breath.

Bubbles

 Voiced by Tara Strong (1998-2015), Kristen Li (2016-present), Kath Soucie (What A Cartoon shorts), Holly Hunter (singing voice in "Tiara Trouble")

 The joy and the laughter

Bubbles is the one in the blue outfit with the blonde hair and pigtails. She's the most childish, naive, and timid of the three, but also the most gentle, caring, and playful. She's a Friend to All Living Things, and she has the unique ability to talk to animals and speak any language.

Buttercup

 Voiced by Elizabeth Daily (1995-2015), Natalie Palamides (2016-present)

 The toughest fighter

Buttercup has the green outfit and black hair. She's a tomboy, and the "toughest fighter". She's the most aggressive and confrontational sister, and has gained a reputation among the bad guys of Townsville as the most vicious of the trio. Unlike her sisters, she doesn't have a unique ability (to her chagrin); however, it's eventually revealed in the Season 6 episode "Nuthin' Special" that she's the only member of the team who can curl her tongue. Well, at least it's something.

Professor Utonium

 Voiced by Tom Kane

Professor Utonium is the brilliant scientist who created the girls in his lab. He acts as a father figure, caring for them as a single parent would. He's enthusiastic about his work, and cooks up all sorts of inventions and experiments in his lab.

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