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- The entire trope is parodied by Homestar Runner in the Strong Bad Email "original", in which Strong Bad claims the current Bubs is merely a replacement for Original Bubs.
- Though it seems that this is more of a Suspiciously Similar Substitute situation, as Original Bubs seems to be a different character. In fact, his name is Original Bubs.
- He also claims there have been "like twelve King of Towns."
- Also, the Cheat Commandos cartoon "On the Next Epi-Snowed" ends with producer A. Chimendez firing the voice actor Crack Stuntman, then inserting himself into the cartoon as Agent Chimendez to explain that Gunhaver was sent on a secret mission to the moon, and when he comes back, his voice might be different.
- Several voice changes have occurred on Happy Tree Friends as cast members left, most of the departures having come for various reasons in 2005:
- Ellen Connell replaced Dana Belben as Cub, Giggles and Petunia. In 2010, she was replaced by Lori Jee, who also voices all three characters.
- Initially, Kenn Navarro voiced only Cuddles. After Mike Giambruno (who voiced both Lifty and Shifty) left the show, Navarro took over those roles. Navarro also voiced Handy in one episode because that character's VA, Warren Graff, was not available. One episode even features both Navarro's and Giambruno's voices for Lifty and Shifty.
- Aubrey Ankrum (Pop and Flippy) left the show at some unknown point. His voice has been sampled for Pop and Flippy's evil side, although Navarro has taken over voicing the latter's good side.
- Francis Carr replaced Jeff Biancalana as Russell.
- David Winn replaced Rhode Montijo, who voiced Lumpy and Splendid.
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