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Dyeing for Your Art: Both Benedict Cumberbatch and Mark Gatiss dye their hair black for their roles as Sherlock and Mycroft. They're both naturally ginger.
In preparation for the first season, Cumberbatch lost some weight to reflect Sherlock's tendency to not eat while working. In the second season, he gained the weight back - after all, Sherlock now shares an apartment with a physician.
Fan Nickname: "Mocklock" has been used in a few comment threads for those that believe that the ambassador's children were kidnapped by someone disguised as Sherlock Holmes, which caused the little girl to freak out when she saw the real Sherlock. Also used to refer to the theory that the dead Sherlock at the end of the episode was a body double, possibly the same body that kidnapped the children.
Since the two producers work so closely together on this, their names have slowly condensed from "Steven Moffat and Mark Gatiss" to "Moffat and Gatiss" to "Moffat-Gatiss" to finally colliding into "Mofftiss."
Emma's actress was, in real life, Benedict Cumberbatch's long-time romantic partner. Puts an interesting spin on Sherlock interrogating Amanda (the murder victim's mistress in episode 2) about her relationship.
And writer Mark Gatiss plays Mycroft. In addition to his writing duties, he also appeared in Doctor Who as Professor Lazarus.
He's also one third of the population of Royston Vasey
Anderson briefly appears in Merlin as the apparent leader of Merlin's home village. And in Hornblower fandom he's known as the Rhumb Line Guy.
Enthusiastic BBC followers may also recognise the master-criminal Jones from My Life in Film.
A blink-and-you'll-miss-it one, but Band of Brothers fangirls might recognize Jim Moriarty as Pvt. "Cowboy" from the second episode, who eventually snaps at Guarnere to "shut [his] fuckin' guinea trap."
The Hounds of Baskerville contained not one, but twoLittle Johns. One is the gay owner of a B'n'B, and the other is an evil scientist.
The news presenter in the story about Baskerville has pulled double Doctor duty as the insect scientist Chantho in "Utopia" and the fortune teller in "Turn Left."
Jen shows up as another supposedly ditzy redhead as Kitty Reilly.
When comparing the characterization of Sherlock in the unaired pilot and the canon, Sherlock comes across as far more sympathetic in the pilot. Considering the actions Sherlock is capable and willing to do in the series, this could ironically enough be a way of making him less creepy.