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- The Chest Burster in RE 2, which evolves into something resembling a Xenomorph.
- Wesker's Matrix style moves, and Terminator sunglasses with flashing red eyes.
- With his glasses off, his orange cat eyes, a reference to Michael Jackson's Thriller.
- Alexia's flammable blood attacks, an ode to Carrie.
- Alexia's second mutation is reminiscent of the breeding form of the Queen from Aliens.
- The cargo elevator escape in Resident Evil 0 is a shout out to the escape sequence at the end of Aliens.
- Osmund Saddler looks and talks like Emperor Palpatine.
- Dr. Salvador resembles both Leatherface, and Jason when he wore a burlap sack mask.
- Resident Evil 4: The Broken Butterfly is a gun that "will make anyone's day".
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