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TG Comics' Jill Trent, She-Sir Science Sleuth: The Remix Comic
In these stories, heroine Jill Trent was once a male janitor named Jim Trent, who was transformed by exposure to the strange element Femavium into a girl -- but a girl who still has the spinal fluid of a man! When the atoms of Jill's Femavium-enhanced blood were mixed with her "Man-Fluid," the interaction gave her brain cells with the proportional density of 58 girls. Together with her fiancée Daisy, she uses her newfound she-science abilities to fight crime!