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Dr. Joffries had the equipment at CHESAPEAKE to do something that would have come very naturally to any researcher: he could sequence the worm's DNA. Shortly after receiving the results from the DNA sequencing he sent a very short email to his colleague and EFRE head Dr. Paul Two-Horses."Paul, it's us."
These are cases where a strange or fantastic creature eventually turns out to actually be a member of homo sapiens - a human being - or a Human Subspecies.
Since humans make up the majority of fictional characters, and being a human isn't (normally) regarded as a strange character attribute, this is often used as an inversion of traditional reveal tropes (such as Not Even Human).
WARNING!! Spoilers ahead!
- The Jovian lizards in Nadesico turned out to be humans.
- Much like the above example, the UE from Gundam AGE are actually members of Vagan, a human nation formed by colonists who were abandoned by the Earth Federal Forces 150 years before the start of the series.
- In Eureka Seven, Anemone's appearance and role (and possibly her name) seem to imply that she is a Coralian. It turns out she's just a human whose appearance and abilities have been modified by horrible military experiments.
- In Claymore, the youma turn out to be humans infested with parasites born from the flesh of the Descendants of Dragons.
- This is one of the twists in Pandorum, the creepy alien mutant cannibals are descended from humans who've evolved to survive in a foodless spaceship over thousands of years. It helped that their ancestors were dosed with a treatment that caused accelerated evolution.
- In Dragonback, the long-lost original hosts of the K'da were called the Dhghem. Turns out that's actually "Human" in a really old language.
- The koloss and kandra from Mistborn both turned out to be transformed humans.
- In The Hobbit, Gollum is described as a strange and nasty creature of undefined origins. In Lord of the Rings, we get to know he's in fact a hobbit whose appearance was twisted by centuries of exposure to the One Ring.
- In Rock-a-Doodle, Edmond was a Baleful Polymorph who had been turned into a kitten, but none of the animals really believed him until he turned back into a human at the end of the movie.
- There's one episode of the original Twilight Zone, titled "The Invaders", where a woman is getting unpleasant visits from tiny alien invaders. But those people turn out to actually be human beings from Earth, and the woman's world is the alien planet, and the alien we've encountered is a humanoid giant.
- An episode of the 1980s Twilight Zone had this as well: In one episode titled "Hunted", a group of soldiers were hunting down a monster known as the Kreetor. Turns out that the Kreetor is a human being, and the people we thought were humans are actually robots. We also initially assume that "Kreetor" is a linguistic devolution of "Creature". Turns out it was actually from the word "Creator".
- In an episode of Star Trek: The Next Generation, transporter-phobic character Barclay, when forced to travel via the transporter, sees some strange virus-like creatures in the matter stream. After suffering greatly due to his fears, he eventually figures out that those strange beings are actually humans, stuck in the pattern buffer.
- Futurama: Leela claims to be an alien cyclops woman who has been trying for years to find her home planet. But she's wrong. She is actually a mutant born from mutated human sewer dwellers on Earth, who gave her up and attached an adoption letter written in alien language as a way to give her a better life.
- (Almost) every last goddamn Scooby Doo villain.