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This may lead sooner or later to Passing the Torch and Retired Badass, or in more cynical works, a Heroic BSOD or a Despair Event Horizon, as the increasingly strung-out and hopeless hero just loses it because he can't save all those people who need him. This could of course apply to the villain, for many of the same reasons (well, presumably not the strain of constantly having to save people, but certainly the stresses of dealing with the superheros and law enforcement would be an issue)
- Played for immense drama in Revolutionary Girl Utena: What led the once-sincerely heroic Prince Dios to become the horribly cruel Magnificent Bastard Akio Ohtori was an Up to Eleven version of this. Not helped by thge crowds being Ungrateful Bastards and almost killing his sister (and soon to be victim) Anthy.
- Utena herself goes through this, especially when she temporarily loses Anthy and when she realises the truth behing everything. Unlike Dios/Akio, she overcomes this at the end and manages to truly save Anthy.
- The first Sailor Moon anime discusses this twice:
- Right after defeating Metallia, Usagi/Moon dies due to overloading the Silver Crystal. Her last words are a wish on the Crystal itself, saying she wants to have a normal life again. When the Crystal revives her, Mamoru and the Senshi, it's without their memories of their fights; when Luna is forced to restore Usagi's own memories, the poor girl is traumatised over it and screams that she doesn't want to remember, but still suits up to save Naru and later quietly says goodbye to her "normal girl's life".
- When Chibiusa screws up BADLY and the Senshi are captured by Rubeus due to this, Usagi tells the Moon Cats that she's getting tired of protecting her all the time, that she cannot do it any longer due to what she did, and that she'd rather hand her over to the enemy. Luna and Artemis are understandably shocked to hear an All-Loving Heroine like her saying such things and Luna even asks if she truly means it; Usagi says that she would never actually do so, but also tearfully adds that she's not an adult able to handle it and that she's truly tired. She still goes off alone to save the girls, then the very remorseful Chibi-Usa follows, and the two manage to teamwork to rescue the kidnapped Senshi
- Constantly happens to poor Spider-Man. He got his powers early in life and no one could help him with them for a long time, his loved ones have been at risk from the start and some of them actually died (plus the death of one of them was a HUGE Wham! Episode for comics in general), he's a BIG Hero with Bad Publicity, etc. It'd be less surprising to have the guy NOT quitting from his heroics more than once in a while.
- Daredevil: We see the hero going through his before-bed routine, getting everything put away in just the right place, climbing into the sound-proof casket (necessary due to his super hearing), only for him to hear a woman somewhere nearby crying for help. He only lets out an exhausted sigh before slowly closing the casket to close out the sound.
- In Megamind, Metroman gets so tired of being a hero all the time he fakes his death.
- Harry Dresden goes through this all the time. Often he will forget to eat, or sleep when he's on a case and the world needs saving from supernatural doom. By the time he manages to solve everything he's usually so strung out that he often ends up just blacking out from exhaustion.
- Alaric Morgan is particularly prone to this in regards his Deryni powers. He is apt to use use his powers literally to the point of falling over at times, unless he he is prevented from doing so. Kelson scolds him for it in The King's Justice, and Azim forbids him from helping with Derry after he and Dhugal have just spent themselves Healing Mátyás in King Kelson's Bride.
- The Curse of Chalion: Poor Cazaril! To list all his tribulations would be a massive wall of text, but to sum up: in the novel, he rides 800 miles on horseback with a demon-infested tumor in his stomach. Before the novel takes place, he holds a fortress against an extended seige, and the starvation and disease that go along with that. Then he's sold into slavery aboard a galley, where he nearly dies to save Chekhov's Oarman. By the end of the novel he has literally almost hero'ed himself to death.
- The protagonist of Beachwalker develops a bad case of this partway through the book as she tries to juggle treating her patient, surviving the aftermath of an earthquake, and a bullet wound all at the same time.
- In Heroes season 4, Peter wore himself to the breaking point trying to rescue and heal people in his job as a paramedic using his abilities.
- In an episode of Lois and Clark, Lois was near the breaking point when she realized that even with all of Superman's (borrowed) powers, she could not save everyone.
- In "The Listener" this turns out to be a plot point. Toby will die if he continues to use his powers and in the second season finale, shuts off his telepathy
- In the Pathfinder Adventure Path Curse of the Crimson Throne, most descriptions of Field Marshal Cressida Kroft--the captain of the city guard and resident Reasonable Authority Figure--stress how exhausted she looks from dealing with the various disasters of the city.
- By Mass Effect 3, Commander Shepard really starts getting hit with this and by the end of the game, even before the final battle, s/he sounds completely exhausted and spent.
- Sailor Nothing has a nasty case of this, to the point of her being constantly on the verge of a complete breakdown. Doesn't help that she gets splitting headaches every time a Yamiko is created, and goes out to fight even when she's badly injured.
- Batman suffers an emotional breakdown like this in the Batman: The Animated Series episode "I am the Night".
- J'onn J'onzz temporarily quits the Justice League late in the third season of Justice League Unlimited partly due to this.