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Gru

Voiced by Steve Carell

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 The title character, a supervillain whose previous schemes including stealing the Times Square Jumbotron, the Statue of Liberty (actually the Las Vegas one) and the Eiffel Tower (also Vegas). When another villain shows him up by stealing the Pyramid of Giza, he decides to top that by stealing the moon. This will require a Shrink Ray, and to get his hands on it, he comes up with a plan involving little girls...

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Vector

Voiced by Jason Segel

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 The primary antagonist of the film, a nerdy young man who just happens to have very good technology. He stole the Pyramid of Giza, which kicks the film off. He took the shrink ray that Gru requires for his plan. Has a thing for sea life.

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Miss Hattie

Voiced by Kristen Wiig

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 Owner of Miss Hattie's Home for Little Girls... which she runs as something of a sweatshop cookie-sales outfit. Under the sweet surface is a cold, ruthless woman who has no affection whatsoever for the girls in her care.

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Agnes

Voiced by Elsie Fisher

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 Youngest of the three girls Gru adopts. She's an oddball who loves unicorns. A lot. The first to take a liking to Gru.

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Edith

Voiced by Dana Gaier

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 Middle of the three girls Gru adopts. Somewhat disagreeable, though she adjusts quickly once Gru's true nature becomes obvious.

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Margo

Voiced by Miranda Cosgrove

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 Oldest of the three girls Gru adopts. She acts as a guardian to her younger "sisters", and as such is slow to trust anyone.

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Dr. Nefario

Voiced by Russell Brand

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 Gru's resident Mad Scientist, builder of the devices he uses in his schemes.

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Mr. Perkins

Voiced by Will Arnett

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 Owner of the Bank of Evil (formerly Lehman Brothers), where supervillains get loans for their schemes. Not a good person.

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...and the Minions

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 A small army of yellow, begoggled people in overalls who do the grunt work for Gru. They adore their boss, who surprisingly enough returns the affection. This doesn't mean they're all that effective sometimes...

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